Perna canaliculus Lipid Complex PCSO-524™ Demonstrated Pain Relief for Osteoarthritis Patients Benchmarked against Fish Oil, a Randomized Trial, without Placebo Control
Aim: To compare, from baseline, pain relief, changes in the indicators of quality of life and safety for osteoarthritis patients taking a patented CO2 stabilised oil from the NZ Greenshell Mussel Perna canaliculus (PCSO-524™) compared with patients taking fish oil (containing an industry standard EPA 18% and DHA 12% blend).
Measurement of pain relief resulting from the administration of lipid complex PCSO-524™ as compared to fish oil for treating patients who suffer from osteoarthritis of knee and/or hip joints Perna canaliculus
Osteoarthritis (OA) typically generates pain, reduced mobility and reduced quality of life. Most conventional treatments for osteoarthritis, such as non-steroidal anti-inflammatory drugs (NSAIDs) and simple analgesics, have side effects. PCSO-524™, a non polar lipid extract from the New Zealand Green Lipped Mussel, is rich in omega-3 fatty acids and has been shown to reduce inflammation in both animal studies and patient trials.
Efficacy of lipid extract from Perna canaliculus in treatment of musculoskeletal diseases in old age
Osteoarthritis is a social disease that has a multi-factorial aetiology. It is the most common rheumatic disease characterised by pain and inflammation due to an involvement of articular cartilage, bone and soft tissues. The prevalence of osteoarthritis increases with age and depends on the presence of risk factors.
Marine lipid extract benefits OA patients
The first double-blind, placebo-controlled clinical trial of Lyprinol® in patients with osteoarthritis (OA) has confirmed its effectiveness in treating the pain associated with the disease and improving mobility. Lyprinol® is a purified marine lipid extract from New Zealand’s green-lipped mussel (Perna canaliculus), consisting of a unique patented combination of lipids and polyunsaturated fatty acids with a high omega-3 to omega-6 ratio.
Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol®)
The Maoris who live in New Zealand have claimed for centuries that consuming local green-lipped mussels helps them maintain good health. Recent statistics show that the reported incidence of arthritis is extremely low in the coastal-dwelling Maoris, who consume large amounts of green-lipped mussels, whereas Maoris who reside in the interior have the same incidence of arthritis as New Zealanders of European origin.
Efficacy and tolerability of mussel-Lyprinol® omega-3-complex on inflammatory rheumatoid disorders
This 12 week drug monitoring study evaluated the effects of Sanhelios mussel-Lyprinol® omega-3-complex, on 50 adult men and women suffering from inflammatory rheumatoid arthritis. 34 of the 50 patients required medicinal treatment before and during the study.